World Journal of Current Medical and Pharmaceutical Research 2021-09-07T21:43:36+0530 WJCMPR Open Journal Systems <p><strong>World Journal of Current Medical and Pharmaceutical Research </strong>(WJCMPR) is a double-blind peer-reviewed bimonthly open access international journal dedicated to the promotion of research in health and Pharmaceutical sciences. We define Open Access-journals as journals that use a funding model that does not charge readers. The journal publishes Research articles, Review article, Case studies and Short communication from broad areas like Medicine, Dentistry, Pharmacy, Anatomy, Physiology, Biochemistry, Neurology, Surgery, Orthopedics, Ophthalmol</p> The prevalence of characteristic corneal ulcer patients in sanglah general hospital, in indonesia 2021-08-11T13:23:08+0530 Sinta Wiranata I Wayan Eka Sutyawan I Putu Budhiastra <p><strong>Purpose</strong>: The purpose of the study was to perceive epidemiology, predisposing and varied risk factors, age, gender, profession, ulcus location, lateralization, visus category, medication. It also determines the relationship between each factor with infection and non-infection in Sanglah General Hospital, Bali.</p> <p><strong>Methods</strong>: This is a cross-sectional study with method was used with 44 patients conferred in the Ophthalmology Department. The purposive sampling technique was also used in this study by considering exclusion and inclusion criteria. Then, the data were analyzed and assessed for medication and surgery for treatment between January 2017 and October 2018 using SPSS 25 version.</p> <p><strong>Results</strong>: The mean age at diagnosis was 49.16±2.58 years, where samples of corneal ulcer infection made up 56.8%, and most of the cases occurred within the age group 30 - 60 years. Meanwhile, the infection mostly occurred in males, at a proportion of 77.3%, and based on the profession, 43.2% of the corneal ulcer were farmers. The most predisposing factor for infectious corneal ulcers was trauma, at 36.4%, as 39 patients had a central ulcus, where 47.7% were infectious, and 36.4% were non-infectious. However, not all the study variables were statistically significant (p &gt; 0.05) with the patient's corneal.</p> <p><strong>Conclusion</strong>: The findings of this study showed that corneal ulcer is common and mostly affects male. Furthermore, the epidemiological trends from developing countries with a predominance of infectious corneal ulcers were additional or less common. Therefore, more analysis with larger and specific sample sizes is required to be developed for resultant analytical research</p> 2021-08-11T00:00:00+0530 Copyright (c) 2021 Sinta Wiranata, I Wayan Eka Sutyawan, I Putu Budhiastra Electro-spun nano fiber of carboxymethyl cellulose – curcumin and its applications 2021-09-07T21:43:36+0530 Afinisha Deepam L.S. Manasi Krishnan Aswathy Sudhakar S Paulraj L S <p>Cellulose is a prominent scaffolding polysaccharide found in plants as micro fibrils which form the structurally strong framework in the cell walls. It has wide variety of uses such as attacking agent, emulsifier, stabilizer etc. Its use can be further enhanced by converting cellulose into cellulose derivatives. One of the most important cellulose derivatives is carboxy methyl cellulose (CMC). In the present study, cellulose is converted to CMC thereby preparing CMC – curcumin nanofiber by using electro spinning method. The functional groups identification was done by using UV Visible spectroscopy and FT-IR. Surface structure was analyzed by using Scanning Electron Microscopy. The antifungal activity was studied against<em> Aspergillus niger</em> and <em>Candida albicans</em>.&nbsp;. The antibacterial activities also studied for the samples against <em>E.coli</em>, <em>Klebsiella pneumonia, Streptococcus mutans and Staphylococcus aureus.</em></p> 2021-08-24T00:00:00+0530 Copyright (c) 2021 AFINISHA DEEPAM Memory Potential Herb: A Review 2021-07-29T09:39:25+0530 Chandrika Sharma Ajeet Pal Singh Amar Pal Singh <p>Memory is an important aspect of cognition. For its health-promoting qualities, Ayurveda is gaining popularity and attention in many areas of the globe. Dementia is a condition in which a person's mental and cognitive abilities gradually deteriorate. Dementia has been related to a number of risk factors and circumstances, including inadequate cerebral blood flow, toxin exposure, mitochondrial malfunction, and oxidative damage, and it often coexists with other neurodegenerative diseases, such as Dementia and memory loss. As a consequence, the present research focuses on the many herbal ayurvedic medicinal plants and their connection to memory functions.</p> 2021-07-25T00:00:00+0530 Copyright (c) 2021 Nyctanthes arbor-tristis: a comprehensive review 2021-07-29T09:53:17+0530 Jaspal Singh Amar Pal Singh Ajeet Pal Singh <p>The Indian medicinal herb Nyctanthes arbor-tristis Linn. (NAT) is well-known. It is often referred to as "Parijat" and is a critically endangered species in India. Crude extracts and refined chemicals from seeds, such as 4-hydroxy-hexahydrobenzofuran-7-one, 6-hydroxyloganin, and Arbortristoside A, a polysaccharide from the leaves, and Naringenin from the stem, may all be sources of active pharmacological agents. In Ayurveda, the plant is used for a variety of pharmacological effects, including anticancer, antiparasitic, antimalarial, immunostimulant, hepatoprotective, antiviral, anti-diabetic, and anti-allergy activity.</p> 2021-07-28T00:00:00+0530 Copyright (c) 2021 The promising oncostatic effects of melatonin against ovarian cancer 2021-09-05T19:56:01+0530 Naba Kumar Das Saptadip Samanta <p>Melatonin is a pineal hormone, secreted at the subjective night. It is involved in the regulation of many physiological functions, including the sleep-wake cycle, gonadal activity, free radical scavenging, immunomodulation, neuro-protection, and cancer progression. Melatonin acts through cell surface receptors (MT1 and MT2) as well as nuclear receptors. Circadian dysfunction can alter the secretion of melatonin. Inappropriate melatonin level promotes the initiation of many pathologies including cancer. Ovarian cancer is a common form of gynecological disease. Several studies indicate the profound link between impaired melatonin secretion and the progression of ovarian cancer. Melatonin exerts oncostatic effects in multiple ways; it acts as a potent antioxidant, induces apoptosis, and regulates metabolism, and chronic inflammatory response in ovarian cancer cells. Moreover, melatonin improves the efficacy of the current treatment regimen of ovarian cancer and can be used as an adjuvant.</p> 2021-08-21T00:00:00+0530 Copyright (c) 2021 Saptadip Samanta, Naba Kumar Das Phytopharmaceutical profile of Ficus thonningii : An updated Review 2021-09-05T19:34:21+0530 Anu Bala Ajeet Pal Singh Amar Pal Singh <p>Ficus thonningii is a plant that is widely utilised in African ethnomedicine to cure a variety of ailments. a rational examination of F. thonningii's nutritional, phytochemical, and pharmacological characteristics in connection to its medicinal uses.Alkaloids, terpenoids, flavonoids, tannins, and active proteins are among the bioactive components found in Ficus thonningii, all of which contribute to its therapeutic qualities.Continue to discover, isolate, and quantify the active components, as well as establish the processes behind its curative powers.</p> 2021-08-31T00:00:00+0530 Copyright (c) 2021 G6Pd deficiency with severe hemolytic anemia: a case report 2021-07-31T13:09:31+0530 Zahoor Hussain Daraz Dr. Berkheez Shabir Dr Rehana Afshan Dr Pramesh Kumar Yadav Dr. Mohamed Rashwan Meselhy shady <p>A 3-year-old boy presented to our atoll hospital in H.A Alif Dhidhoo, with severe pallor, jaundice, easy fatigability and recurrent episodes of passage of dark-colored urine for past 3 days. He was born mature at 39 weeks of gestation with no past significant medical history. Recent history revealed the consumption of 2 cans of fava beans and application of some medicinal herbs. On admission, physical examination revealed fever of 101 degree Fahrenheit, severe pallor, jaundice, cervical lymphadenopathy and mild hepatomegaly. Laboratory investigation results showed a hemoglobin level of 5.4 g/dl with a hemolytic blood picture and serum Bilirubin of 6mg/dl. The patient's G6PD level was measured which showed marked deficiency. Other causes of hemolytic anemia were excluded. Patient required urgent packed RBC transfusion and antibiotics for infection. He responded well to the treatment and was discharged in a stable condition. Parents were appropriately advised on the condition and the importance of avoiding certain foods and medication. Folic acid was prescribed for maintaining normal hemoglobin concentration. This is a first case report in North Maldives of G6PD presenting with severe hemolytic anemia requiring blood transfusion.</p> 2021-07-31T00:00:00+0530 Copyright (c) 2021 Zahoor Hussain Daraz, Dr. Berkheez Shabir, Dr Rehana Afshan, Dr Pramesh Kumar Yadav, Dr. Mohamed Rashwan Meselhy shady Recurrent pleural effusion in patient with liver cirrhosis – a case report 2021-09-05T19:42:22+0530 Diah Pradnya Paramita Putu Indri Widiani I Wayan Sunaka <p>Liver cirrhosis is caused by necrosis of liver cells leading to fibrosis and nodule formation. Structural abnormalities of the liver causing impaired hepatocyte function and portal hypertension. Hepatic hydrothorax is a less common pulmonary complication of portal hypertension. We present a 47 years old man with liver cirrhosis and recurrent massive pleural effusion. Diagnosis can be challenging because it can be associated with pulmonary or systemic disorders. Pleural fluid analysis is necessary to differentiate transudate or exudate as the cause of pleural effusion. Thoracentesis is done to reduce the complaints experienced by the patient.</p> 2021-08-31T00:00:00+0530 Copyright (c) 2021 Diah Pradnya Paramita, Putu Indri Widiani, I Wayan Sunaka