A REVIEW ON PLANT DERIVED MULTITARGET THERAPEUTIC PHYTOMOLECULE - EMBELIN
Abstract
Embelin is a multi targeted therapeutic agent extracted from fruits of Embelia ribes. It exhibits various bioactivities making it a vital molecule of future research. This article focuses on various pharmacological activities involved by Embelin. The plant exhibit extensive pharmacological activities such as wound healing, hypoglycemic, cardiovascular, antioxidant, antimicrobial, antidiabetic and anti fertility.
Keywords:
Multi-Targeted, Therapeutic Agent, Fruits of Embelia Ribes, Embelin, Plant Derived, Phytomolecule
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References
1. Hong Lu, Jun Wang, Youxue Wang, Liang Qiao. Yongning Zhou .Embelin And Its Role in Chronic Diseases. Advexp Med Biol. 2016; 928: 397–418.
2. K. Souravi and P. E. Rajasekharan.Ethnopharmacological Uses of Embeliaribesburm. F. - A Reviewiosr Journal of Pharmacy and Biological Sciences.2014; 9(3): 23-30.
3. Satishgudala, Archi Sharma, V. Rajeswer Rao, Awanish Kumar And Santhoshpenta Recent Developments In Synthesis Of Embelin Heterocyclic Derivatives And Their Biological Applications,Chemical Papers 2017;72(5):1065-1080
4. Tprabhu Ks, Siveen Ks, Kuttikrishnan.Targeting Of X-Linked Inhibitor Of Apoptosis Protein And Pi3-Kinase/Akt Signaling By Embelin Suppresses Growth Of Leukemic Cells. Plos One. 2017;12(7).
5. Irmapodolak, Agnieszkagalanty, Zbigniewjaneczko.Cytotoxic Activity of Embelin from Lysimachiapunctatefitoterapia. 2005 Jun; 76(3-4): 333–335.
6. Zhou, Xl. Huang, L. & Cao, J. Embelin Reduces Systemic Inflammation and Ameliorates Organ Injuries in Septic Rats Throughdownregulating Stat3 and Nf-Κb Pathwaysinflammation. 2015; 38: 1556.
7. Zhenyixue, Zhenzhenge, Kai Zhang, Rui Sun, Juhong Yang, Rong Han, Meiyupeng, Yan Li, Wen Li, Da Zhang, Et Al.Molneurobiol.Embelin Suppresses Dendritic Cell Functions And Limits Autoimmune Encephalomyelitis Through The Tgf-Β/Β-Catenin And Stat3 Signaling Pathwaysmolneurobiol.2014 ; 49(2): 1087–1101.
8. Ashique Shaikh, Shivsharan B. Dhadde, Sharanbasappadurg, V. P. Veerapur, S. Badami, B. S. Thippeswamy, Jagadevappa S. Patilphytother Res. Effect Of Embelin Against Lipopolysaccharide-Induced Sickness Behaviour In Micephytother Res.2016 ; 30(5): 815–82).
9. Ravi Joshi, J P Kamat, Tulsi.Mukherjee.Free Radical Scavenging Reactions And Antioxidant Activity Of Embelin: Biochemical And Pulse Radiolyticstudies .Chemico-Biological Interactions.2007; 167(2), : 125-34.
10. Arora R, Deshmukh Rembelin Attenuates Intracerebroventricularstreptozotocin-Induced Behavioral, Biochemical And Neurochemical Abnormalities In Rats.Molneurobiol.2017 ; 54(9):6670-6680.
11. C.A. Hill, M.L. Alexander, L.D. Mccullough, R.H. Fitchinhibition Of X-Linked Inhibitor Of Apoptosis With Embelin Differentially Affects Male Versus Female Behavioral Outcome Following Neonatal Hypoxia-Ischemia In Ratsdevneurosci. 2012 ; 33(6): 494–504..
12. Mahendran S1, Thippeswamy Bs, Veerapur Vp, Badami S. Anticonvulsant Activity Of Embelinisolated From Embeliaribes. Phytomedicine. 2011;18(2-3):186-8.
13. Dhadde Sb, Nagakannan P, Roopesh M, Anand Kumar Sr, Thippeswamybs,Veerapurvp, Badami S.Effect Of Embelin Against 3-Nitropropionic Acid-Induced Huntington's Disease In Rats .Biomed Pharmacother.2016 ;77:528.
14. Simone Reuter, Sahdeo Prasad, Kanokkarnphromnoi, Ramaswamykannappan, Vivek R. Yadav, Bharat B. Aggarwal.Embelin Suppresses Osteoclastogenesis Induced By Rankl And Tumor Cells In Vitro Through Inhibition Of The Nf-Κb Cell Signaling Pathway.Mol Cancer Res.2010 ; 8(10): 1425–1436.
15. M. Chitra, E. Sukumar, V. Suja, C. S. Devi. Antitumor, Anti-Inflammatory And Analgesic Property Of Embelin, A Plant Product .Chemotherapy.1994 ; 40(2): 109–113.
16. Gandhi Gr, Stalin A, Balakrishna K, Ignacimuthu S, Paulraj Mg, Vishal R. Insulin Sensitization Via Partial Agonism Of Pparγ And Glucose Uptake Through Translocation And Activation Of Glut4 In Pi3k/P-Akt Signaling Pathway By Embelin In Type 2 Diabetic Rats..Biochimbiophysacta.2013 ;1830(1):2243-55.
17. Ning Nz, Liu X, Chen F, Zhou P, Hu L, Huang J, Li Z, Huang J, Li T, Wang H.Embelin Restores Carbapenem Efficacy Against Ndm-1-Positive Pathogens .Front Microbiol..2018 25;9-71.
18. S. Agrawal, S. Chauhan, R. Mathurandrologia.Antifertility Effects of Embelin In Male Rats. Molecules.1986; 18(2): 125–131.
19. Kalyan Kumar G, Dhamotharan R, Kulkarni Nm, Mahat My, Gunasekaran J, Ashfaquem.Embelin Reduces Cutaneous Tnf-Α Level and Ameliorates Skin Edema in Acute and Chronic Model of Skin Inflammation in Mice.Eur J Pharmacol. 2011 ;15; 662(1-3):63-9.
20. Siddalingappatippannabhagawati, Sharanbasappadurgembelin Lipid Nanospheres For Enhanced Treatment Of Ulcerative Colitis - Preparation, Characterization And In Vivo Evaluation.Eur J Pharm Sci. 2015 ; 30; 76: 73–82.
21. N. Radhakrishnan, V. Kavitha, Stk. Raja, A. Gnanamani.Embelin. A Natural Potential Cosmetic Agent.J. Appl. Cosmetol. 2011; 29: 81-89.
22. Dharmendra Singh, Ruchi Singh, Pahup Singh, Radhey S. Guptabasic .Clinpharmacoltoxicol. 2009; 105(4): 243–248.
23. Bhandari U, Ansari Mn, Islam F.Cardioprotective Effect of Aqueous Extract of Embeliaribesburm Fruits against Isoproterenol-Induced Myocardial Infarction in Albino Rats.Indian J Exp Biol. 2008 ;46(1):35-40
24. Y Gao, J Li, X Xu, S Wang, Y Yang, J Zhou, L Zhang, F Zheng, X Li&B Wang.Embelin Attenuates Adipogenesis And Lipogenesis Through Activating Canonical Wnt Signaling And Inhibits High-Fat Diet-Induced Obesity.International Journal Of Obesity .2017; 41(5):729–738
25. R. L. Shirole, N. L. Shirole, M. N. Sarafembeliaribes Ameliorates Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome.Ethnopharmacol .2015 20; 168: 356–363.
26. Durg S, B Nk, Vandal R, Dhadde Sb, Thippeswamy Bs, Veerapur Vp, Badami S, Antipsychotic Activity Of Embelin Isolated From Embeliaribes: A Preliminary Study.Biomed Pharmacother. 2017 ;90:328-331.
27. Akbar, Z., Banji, D. &Deshmukh, P .Prevention Of Cisplatin-Induced Nephrotoxicity by Ethanolic Extract of Embeliaribes Fruits and Αtocopherol In Experimental Animals. Journal Of Complementary And Integrative Medicine 2010; 7(1):1553-3840.
28. Sunitaamrutesh, J Malini, Prakash S Tandur, Pralhad S Patki Clinical Evaluation of a Novel Herbal Dental Cream in Plaque Formation: A Double-Blind, Randomized, Controlled Clinical Trial.Jexppharmacol. 2010; 2: 105–109.
29. Gaurav Gupta1, Imran Kazmi1, Muhammad Afzal1, Gaurav Upadhyay1, Rajnish Singh2, Solomon Habtemariam3.Antidepressant-Like Activity of Embelin Isolated From Embeliaribes.Phytopharmacology. 2013; 4(1): 87-95.
30. Kanthamsrinivas, Ch. Mahesh1, N. Jagadeesh. Anti-Mitotic Activity of Embelin Derivatives. International Journal of Phytopharmacology.2010; 1(2): 98-103
31. Narayanaswamyradhakrishnan, Arumugamgnanamani, Nagarajanrajendra Prasad &Asitbaranmandal .Inhibition Of Uvb-Induced Oxidative Damage And Apoptotic Biochemical Changes In Human Lymphocytes By 2,5-Dihydroxy-3-Undecyl-1,4-Benzoquinone (Embelin),(International Journal Of Radiation Biology 2012; 88:8: 575-582.
32. Prakash, A. O. Short Term Toxicity of Embelin in Female Rats. Phytotherapyresearc., 1994;8(5:, 257–264.
33. Meenakshisundaramsreepriya, Geethabalimol.. Effects of Administration of Embelin and Curcumin on Lipid Peroxidation, Hepatic Glutathione Antioxidant Defense and Hematopoietic System during N-Nitrosodiethylamine/Phenobarbital-Induced Hepatocarcinogenesis in Wistar Rats. Cell Biochem. 2006;284 (1-2): 49-55.
34. Radhikapoojari, Sanjay Gupta, Girishmaru, Bharat Khade, Sanjay Bhagwatasian.Chemopreventive And Hepatoprotective Effects of Embelin On N-Nitrosodiethylamine And Carbon Tetrachloride Induced Preneoplasia And Toxicity In Rat Liver. Pac J Cancer Prev. 2010; 11(4): 1015–1020.
35. Aurelia Lugea, Hongxianghui, Guido Eibl, Qing-Yi Lu, Aune Moro, Xuyang Lu, Gang Li, Vay-Liang Go, Stephen J. Pandolnutr.Ellagic Acid and Embelin Affect Key Cellular Components of Pancreatic Adenocarcinoma, Cancer and Stellate Cells. Mouadedderkaoui Cancer. Author Manuscript; 2013; 65(8): 1232–1244.
36. U. Zutshi, S. C. Sharma, J. L. Kaul, C. K. Atal. Kinetic Fate of Potassium Embelate, A Non-Narcotic Centrally Acting Analgesic after Oral and Intravenous Administration. Pharmacology. 1990; 40(3): 179–184.
37. Johri R.K., Dhar S.K., Pahwa G.S., Sharma S.C., Kaul J.L., Zutshiu.Toxicity Studies With Potassium Embelate, A New Analgesic Compound. Indian J. Exp. Biol. 1990;28: 213–217.
2. K. Souravi and P. E. Rajasekharan.Ethnopharmacological Uses of Embeliaribesburm. F. - A Reviewiosr Journal of Pharmacy and Biological Sciences.2014; 9(3): 23-30.
3. Satishgudala, Archi Sharma, V. Rajeswer Rao, Awanish Kumar And Santhoshpenta Recent Developments In Synthesis Of Embelin Heterocyclic Derivatives And Their Biological Applications,Chemical Papers 2017;72(5):1065-1080
4. Tprabhu Ks, Siveen Ks, Kuttikrishnan.Targeting Of X-Linked Inhibitor Of Apoptosis Protein And Pi3-Kinase/Akt Signaling By Embelin Suppresses Growth Of Leukemic Cells. Plos One. 2017;12(7).
5. Irmapodolak, Agnieszkagalanty, Zbigniewjaneczko.Cytotoxic Activity of Embelin from Lysimachiapunctatefitoterapia. 2005 Jun; 76(3-4): 333–335.
6. Zhou, Xl. Huang, L. & Cao, J. Embelin Reduces Systemic Inflammation and Ameliorates Organ Injuries in Septic Rats Throughdownregulating Stat3 and Nf-Κb Pathwaysinflammation. 2015; 38: 1556.
7. Zhenyixue, Zhenzhenge, Kai Zhang, Rui Sun, Juhong Yang, Rong Han, Meiyupeng, Yan Li, Wen Li, Da Zhang, Et Al.Molneurobiol.Embelin Suppresses Dendritic Cell Functions And Limits Autoimmune Encephalomyelitis Through The Tgf-Β/Β-Catenin And Stat3 Signaling Pathwaysmolneurobiol.2014 ; 49(2): 1087–1101.
8. Ashique Shaikh, Shivsharan B. Dhadde, Sharanbasappadurg, V. P. Veerapur, S. Badami, B. S. Thippeswamy, Jagadevappa S. Patilphytother Res. Effect Of Embelin Against Lipopolysaccharide-Induced Sickness Behaviour In Micephytother Res.2016 ; 30(5): 815–82).
9. Ravi Joshi, J P Kamat, Tulsi.Mukherjee.Free Radical Scavenging Reactions And Antioxidant Activity Of Embelin: Biochemical And Pulse Radiolyticstudies .Chemico-Biological Interactions.2007; 167(2), : 125-34.
10. Arora R, Deshmukh Rembelin Attenuates Intracerebroventricularstreptozotocin-Induced Behavioral, Biochemical And Neurochemical Abnormalities In Rats.Molneurobiol.2017 ; 54(9):6670-6680.
11. C.A. Hill, M.L. Alexander, L.D. Mccullough, R.H. Fitchinhibition Of X-Linked Inhibitor Of Apoptosis With Embelin Differentially Affects Male Versus Female Behavioral Outcome Following Neonatal Hypoxia-Ischemia In Ratsdevneurosci. 2012 ; 33(6): 494–504..
12. Mahendran S1, Thippeswamy Bs, Veerapur Vp, Badami S. Anticonvulsant Activity Of Embelinisolated From Embeliaribes. Phytomedicine. 2011;18(2-3):186-8.
13. Dhadde Sb, Nagakannan P, Roopesh M, Anand Kumar Sr, Thippeswamybs,Veerapurvp, Badami S.Effect Of Embelin Against 3-Nitropropionic Acid-Induced Huntington's Disease In Rats .Biomed Pharmacother.2016 ;77:528.
14. Simone Reuter, Sahdeo Prasad, Kanokkarnphromnoi, Ramaswamykannappan, Vivek R. Yadav, Bharat B. Aggarwal.Embelin Suppresses Osteoclastogenesis Induced By Rankl And Tumor Cells In Vitro Through Inhibition Of The Nf-Κb Cell Signaling Pathway.Mol Cancer Res.2010 ; 8(10): 1425–1436.
15. M. Chitra, E. Sukumar, V. Suja, C. S. Devi. Antitumor, Anti-Inflammatory And Analgesic Property Of Embelin, A Plant Product .Chemotherapy.1994 ; 40(2): 109–113.
16. Gandhi Gr, Stalin A, Balakrishna K, Ignacimuthu S, Paulraj Mg, Vishal R. Insulin Sensitization Via Partial Agonism Of Pparγ And Glucose Uptake Through Translocation And Activation Of Glut4 In Pi3k/P-Akt Signaling Pathway By Embelin In Type 2 Diabetic Rats..Biochimbiophysacta.2013 ;1830(1):2243-55.
17. Ning Nz, Liu X, Chen F, Zhou P, Hu L, Huang J, Li Z, Huang J, Li T, Wang H.Embelin Restores Carbapenem Efficacy Against Ndm-1-Positive Pathogens .Front Microbiol..2018 25;9-71.
18. S. Agrawal, S. Chauhan, R. Mathurandrologia.Antifertility Effects of Embelin In Male Rats. Molecules.1986; 18(2): 125–131.
19. Kalyan Kumar G, Dhamotharan R, Kulkarni Nm, Mahat My, Gunasekaran J, Ashfaquem.Embelin Reduces Cutaneous Tnf-Α Level and Ameliorates Skin Edema in Acute and Chronic Model of Skin Inflammation in Mice.Eur J Pharmacol. 2011 ;15; 662(1-3):63-9.
20. Siddalingappatippannabhagawati, Sharanbasappadurgembelin Lipid Nanospheres For Enhanced Treatment Of Ulcerative Colitis - Preparation, Characterization And In Vivo Evaluation.Eur J Pharm Sci. 2015 ; 30; 76: 73–82.
21. N. Radhakrishnan, V. Kavitha, Stk. Raja, A. Gnanamani.Embelin. A Natural Potential Cosmetic Agent.J. Appl. Cosmetol. 2011; 29: 81-89.
22. Dharmendra Singh, Ruchi Singh, Pahup Singh, Radhey S. Guptabasic .Clinpharmacoltoxicol. 2009; 105(4): 243–248.
23. Bhandari U, Ansari Mn, Islam F.Cardioprotective Effect of Aqueous Extract of Embeliaribesburm Fruits against Isoproterenol-Induced Myocardial Infarction in Albino Rats.Indian J Exp Biol. 2008 ;46(1):35-40
24. Y Gao, J Li, X Xu, S Wang, Y Yang, J Zhou, L Zhang, F Zheng, X Li&B Wang.Embelin Attenuates Adipogenesis And Lipogenesis Through Activating Canonical Wnt Signaling And Inhibits High-Fat Diet-Induced Obesity.International Journal Of Obesity .2017; 41(5):729–738
25. R. L. Shirole, N. L. Shirole, M. N. Sarafembeliaribes Ameliorates Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome.Ethnopharmacol .2015 20; 168: 356–363.
26. Durg S, B Nk, Vandal R, Dhadde Sb, Thippeswamy Bs, Veerapur Vp, Badami S, Antipsychotic Activity Of Embelin Isolated From Embeliaribes: A Preliminary Study.Biomed Pharmacother. 2017 ;90:328-331.
27. Akbar, Z., Banji, D. &Deshmukh, P .Prevention Of Cisplatin-Induced Nephrotoxicity by Ethanolic Extract of Embeliaribes Fruits and Αtocopherol In Experimental Animals. Journal Of Complementary And Integrative Medicine 2010; 7(1):1553-3840.
28. Sunitaamrutesh, J Malini, Prakash S Tandur, Pralhad S Patki Clinical Evaluation of a Novel Herbal Dental Cream in Plaque Formation: A Double-Blind, Randomized, Controlled Clinical Trial.Jexppharmacol. 2010; 2: 105–109.
29. Gaurav Gupta1, Imran Kazmi1, Muhammad Afzal1, Gaurav Upadhyay1, Rajnish Singh2, Solomon Habtemariam3.Antidepressant-Like Activity of Embelin Isolated From Embeliaribes.Phytopharmacology. 2013; 4(1): 87-95.
30. Kanthamsrinivas, Ch. Mahesh1, N. Jagadeesh. Anti-Mitotic Activity of Embelin Derivatives. International Journal of Phytopharmacology.2010; 1(2): 98-103
31. Narayanaswamyradhakrishnan, Arumugamgnanamani, Nagarajanrajendra Prasad &Asitbaranmandal .Inhibition Of Uvb-Induced Oxidative Damage And Apoptotic Biochemical Changes In Human Lymphocytes By 2,5-Dihydroxy-3-Undecyl-1,4-Benzoquinone (Embelin),(International Journal Of Radiation Biology 2012; 88:8: 575-582.
32. Prakash, A. O. Short Term Toxicity of Embelin in Female Rats. Phytotherapyresearc., 1994;8(5:, 257–264.
33. Meenakshisundaramsreepriya, Geethabalimol.. Effects of Administration of Embelin and Curcumin on Lipid Peroxidation, Hepatic Glutathione Antioxidant Defense and Hematopoietic System during N-Nitrosodiethylamine/Phenobarbital-Induced Hepatocarcinogenesis in Wistar Rats. Cell Biochem. 2006;284 (1-2): 49-55.
34. Radhikapoojari, Sanjay Gupta, Girishmaru, Bharat Khade, Sanjay Bhagwatasian.Chemopreventive And Hepatoprotective Effects of Embelin On N-Nitrosodiethylamine And Carbon Tetrachloride Induced Preneoplasia And Toxicity In Rat Liver. Pac J Cancer Prev. 2010; 11(4): 1015–1020.
35. Aurelia Lugea, Hongxianghui, Guido Eibl, Qing-Yi Lu, Aune Moro, Xuyang Lu, Gang Li, Vay-Liang Go, Stephen J. Pandolnutr.Ellagic Acid and Embelin Affect Key Cellular Components of Pancreatic Adenocarcinoma, Cancer and Stellate Cells. Mouadedderkaoui Cancer. Author Manuscript; 2013; 65(8): 1232–1244.
36. U. Zutshi, S. C. Sharma, J. L. Kaul, C. K. Atal. Kinetic Fate of Potassium Embelate, A Non-Narcotic Centrally Acting Analgesic after Oral and Intravenous Administration. Pharmacology. 1990; 40(3): 179–184.
37. Johri R.K., Dhar S.K., Pahwa G.S., Sharma S.C., Kaul J.L., Zutshiu.Toxicity Studies With Potassium Embelate, A New Analgesic Compound. Indian J. Exp. Biol. 1990;28: 213–217.
Published
31-10-2019
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1.
R DB, Majeed MSPS, Joy DM, Parveen H. A REVIEW ON PLANT DERIVED MULTITARGET THERAPEUTIC PHYTOMOLECULE - EMBELIN. World Journal of Current Med and Pharm Research [Internet]. 2019Oct.31 [cited 2024Sep.15];1(5):166-73. Available from: https://www.wjcmpr.com/index.php/journal/article/view/35
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