• V. Satyanarayana Nalanda Institute of Pharmaceutical Sciences, Kantepudi, Guntur, AP
  • D.R. Brahamareddy Nalanda Institute of Pharmaceutical Sciences, Kantepudi, Guntur, AP
  • V.Jayasurya,K. Lakshmipriyanka Nalanda Institute of Pharmaceutical Sciences, Kantepudi, Guntur, AP
  • P. Revathi Nalanda Institute of Pharmaceutical Sciences, Kantepudi, Guntur, AP


Intracerebral haemorrhage is when blood suddenly bursts into brain tissue,causing damage to brain.Intracerebral haemorrhage is an important health problem leading to high rates of death and disability in adults. And it is the most devastating and disabling type of stroke. Uncontrolled hypertension is one of the most common causes for spontaneous intracerebral haemorrhage. Although the number of hospitals for admission for ICH has increased worldwide in past 10 years, mortality has not fallen. Significant treatment approaches include, early diagnosis and haemostasis, aggressive management of hypertension. Factors such as chronic hypertension; cerebral amyloid angiopathy and anticoagulation are commonly associated with intracerebral haemorrhage. Chronic arterial hypertension represents the major risk factor for bleeding. The incidence of hypertension related intracerebral haemorrhage is decreasing in some regions due to improvements of treatments in the chronic hypertension, anti-coagulant related ICH (vitamin-k antagonist and new oral coagulant drugs), represent an increase in the cause of ICH.

Keywords: Intracerebral hemorrhage, Uncontrolled hypertension, clinical management, Anti-coagulation, Cerebral amyloid angiopathy


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1. Qureshi AI, TuhrimS.Broderick ,et al. spontaneous intracerebral haemorrhage.2001;344:1450-60.
2. Labovitz DL ,Haliw A . Boden – Albala B , et al. The incidence of deep and lobar intracerebral haemorrhage in whites, blacks and Hispanics, Neurology; 2005;65:518-22.
3. Sudlow CI , Warlow CP , Comparable studies of the incidence of stroke and its pathological types : Result from an international collaboration . Stroke 1997 ; 28:491-99.
4. American heart organization (accesed Nov 21 , 2007 ) international cardiovascular disease stastics : Cardiovascular disease ( CVD).
5. Feigin VL , Lawes CMM, Bennett DA, et al. stroke epidemiology; a review of population- based studies of incidence, prevelance and case fertility in the late 20 th century, Lancet neurol. 2003;243-253,
6. Feigin VL, Lawes CMM, et al. incidence, case fertility and functional out coms of intracerebral haemorrhage over time according to age, sex and ethnic origin; a systematic review and meta-analysis, Lancet neuro 2010, 9.167-76.
7. Zuhuranec DB,Gonzales NR , et al.presentation of intracerebral haemorrhage in a community, J.neurolNerosuigpsychiat 2006,77:340-4.
8. +Flaherly M , Wood , Haverbusch M , et al .Rational variations in locations and risk of ICH . Stroke , 2005 ; 36 (5) :934 – 7 .
9. Arisen MJ , Clavs SP , et al . Risk factors for ICH , A systemic review stroke 2003 ; 34 (8):2060 – 5 .
10. Brott T, Broderick J, Kothari R, et al. Early hemorrhage growth in patients with intracerebral hemorrhage. Stroke. 1997;28:1-5.
11. Kazui S, Naritomi H, Yamamoto H, et al. Enlargement of spontaneous intracerebral hemorrhage: incidence and time course. Stroke. 1996;27:1783-7.
12. Kazui S, Minematsu K, Yamamoto H, et al. Predisposing factors to enlargement of spontaneous intracerebral hematoma. Stroke. 1997;28:2370-5.
13. Becker KJ, Baxter AB, Bybee HM, et al. Extravasation of radiographic contrast is an independent predictor of death in primary intracerebral hemorrhage. Stroke. 1999;30:2025-32.
14. Ohwaki K, Yano E, Nagashima H, et al. Blood pressure management in acute intracerebral hemorrhage: relationship between elevated blood pressure and hematoma enlargement. Stroke. 2004; 35:1364-7.
15. Toyoda K, Okada Y, Minematsu K, et al. Antiplatelet therapy contributes to acute deterioration of intracerebral hemorrhage. Neurology. 2005; 65: 1000-04.
16. Yasaka M, Minematsu K, Naritomi H, et al. Predisposing factors for enlargement of intracerebral hemorrhage in patients treated with warfarin. ThrombHaemost. 2003; 89: 278-83.
17. Hachinski V, vascular behavioural and cognitive disorders stroke. 2003;34:2775.
18. Carpenter AM, Singh IP, et al, genetic risk factors for SICH,2015;12(1):40-9, dot: Q1038/nmeurol 2015226
19. Bailey RD. Hart RG, et al, reccurent brain hemorrhage is more frequent than ischemic stroke after intracranial hemorrhage, neurology 2001:50;773-77.
20. Hemphill JC, Greenberg SM, Anderson CS, et al. Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals from the American Heart Association/American Stroke Association. Stroke. 2015;46(7):2032–60.
21. Jauch EC, Pineda JA, Claude HJ. Emergency neurological life support: intracerebral hemorrhage. Neurocrit Care. 2015;23 Suppl 2:83–93.
22. Maas MB, Berman MD, Guth JC, Liotta EM, Prabhakaran S, Naidech AM. Neurochecks as a biomarker of the temporal profile and clinical impact of neurologic changes after intracerebral hemorrhage. J Stroke Cerebrovasc Dis. 2015;24(9):2026–31.
23. Maas MB, Rosenberg NF, Kosteva AR, et al. Surveillance neuroimaging and neurologic examinations affect care for intracerebral hemorrhage. Neurology. 2013;81(2):107–12.
24. Rincon F, Mayer S. Clinical review: Critical care management of spontaneous intracerebral hemorrhage. Critical Care. 2008;12(6):237.
25. Goldstein J, Gilson A. Critical Care Management of Acute Intracerebral Hemorrhage. Current Treatment Options in Neurology. 2011;13(2):204–216.
26. Morgenstern LB, et al. Guidelines for the Management of Spontaneous Intracerebral Hemorrhage. Stroke. 2010;41(9):2108–2129.
27. Anderson CS, et al. Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial. The Lancet Neurology. 2008;7(5):391–399.
28. Antihypertensive treatment of acute cerebral hemorrhage. Crit Care Med. 2010;38(2):637–48.
29. Qureshi A, Palesch Y. Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH) II: Design, Methods, and Rationale. Neurocritical Care. 2011;15(3):559–576.
30. Delcourt C, et al. The second (main) phase of an open, randomised, multicentre study to investigate the effectiveness of an intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT2) International Journal of Stroke. 2010;5(2):110–116.
31. Goldstein JN, et al. Risk of thromboembolism following acute intracerebral hemorrhage. Neurocrit Care. 2009;10(1):28–34.
32. Gurol M, Greenberg S. Management of intracerebral hemorrhage. Current Atherosclerosis Reports. 2008;10(4):324–331.
33. Thompson BB, et al. Prior antiplatelet therapy and outcome following intracerebral hemorrhage: a systematic review. Neurology. 2010;75(15):1333–42.
34. Naidech AM, et al. Early platelet transfusion improves platelet activity and may improve outcomes after intracerebral hemorrhage. Neurocrit Care. 2012;16(1):82–7.
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How to Cite
Satyanarayana, V., D. Brahamareddy, V. Lakshmipriyanka, and P. Revathi. “A REVIEW ON CURRENT MANAGEMENT OF NON-TRAUMATIC SPONTANEOUS INTRACEREBRAL HAEMORRHAGE”. World Journal of Current Medical and Pharmaceutical Research, Vol. 1, no. 4, Aug. 2019, pp. 107-12, https://www.wjcmpr.com/index.php/journal/article/view/25.
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